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Shuichi Iino Selected Research

napabucasin

6/2023A Phase I Study to Investigate the Safety, Tolerability and Pharmacokinetics of Napabucasin Combined with Sorafenib in Japanese Patients with Unresectable Hepatocellular Carcinoma.
11/2021Phase I study of napabucasin in combination with FOLFIRI + bevacizumab in Japanese patients with metastatic colorectal cancer.
10/2021Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers.
1/2020Phase 1 study of napabucasin, a cancer stemness inhibitor, in patients with advanced solid tumors.
5/2019A Phase I Study of Napabucasin Plus Paclitaxel for Japanese Patients With Advanced/Recurrent Gastric Cancer.

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Shuichi Iino Research Topics

Disease

3Neoplasms (Cancer)
11/2021 - 01/2020
2Colorectal Neoplasms (Colorectal Cancer)
11/2021 - 01/2020
2Disease Progression
01/2020 - 05/2019
1Hepatocellular Carcinoma (Hepatoma)
06/2023
1Diarrhea
06/2023
1Stomach Neoplasms (Stomach Cancer)
05/2019

Drug/Important Bio-Agent (IBA)

5napabucasinIBA
06/2023 - 05/2019
1Sorafenib (BAY 43-9006)FDA Link
06/2023
1Oxidoreductases (Dehydrogenase)IBA
11/2021
1NAD (NADH)IBA
11/2021
1quinone (benzoquinone)IBA
11/2021
1Bevacizumab (Avastin)FDA Link
11/2021
1Irinotecan (Camptosar)FDA LinkGeneric
11/2021
1Leucovorin (Folinic Acid)FDA Link
11/2021
1Fluorouracil (Carac)FDA LinkGeneric
11/2021
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2021
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2020
1Paclitaxel (Taxol)FDA LinkGeneric
05/2019

Therapy/Procedure

1Drug Therapy (Chemotherapy)
11/2021
1Therapeutics
01/2020